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KMID : 0388019950060030140
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Korean Journal Gynecologic Oncology and Colposcopy
1995 Volume.6 No. 3 p.140 ~ p.156
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Clinical Significance of Human Papillomavirus Infection and Epidermal Growth Factor Receptor in Cervical Carcinoma
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강순범
박창수/전혜원/김종훈/박노현/송용상/이효표
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Abstract
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inoma of uterine cervix is the most common malignant tumor in Korean women but the pathogenesis of that is not well known. Recently human papillomavirus(HPV), especially type 16 and 18, ras and c-erb-B oncogenes and epidermal growth tactor
receptor(EGFR) have been known to be implicated in the oncogenesis of cervical carcinoma.
Fifty two women treated for invasive squamous cell carcinoma of uterine cervix and thirty three normal controls were studied to investigate the role of the infection of HPV type 16, 18 nd the expression of EGFR in tumorigenesis and progression of
cervical cancer and to investigate the correlation between the infection of HPV and the expression of EGFR I cervical cancer. The presence of HPV DNA was analysed using HPV amplitication by polymerase chain reaction(PCR), and the expression of
EGFR
by
immunohistochemical staining. The HPV 16/18 DNA were detected in 40 of 52(76.9%) cervical cancer tissues while in 6 of 33(18.2%) control(p<0.05). The expression of EGFR was positive in 27 of 52(51.9%) cervical cancer while in none control tissues
(p<0.05). The infection of HPV 16/18 and expression of EGFR were not significantly associated with the age, stage, histologic type, lymph node metastases, tumor size, invasive depth of cervical wall and 5-year survival rate.
There was no significant correlation between HPV positivity and EGFR expression in cervical cancer patients.
These data suggest that HPV infection and EGFR expression might play a role in carcinogenesis but not in the progression or metastasis of cervical cancer.
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KEYWORD
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